Dr David Pulido-Gomez
I am College Lecturer in Biochemistry (Molecular and Structural Biology) at St Peter’s and a Senior Postdoctoral Scientist working in Professor Simon J. Draper's laboratory at the Jenner Institute, University of Oxford. My research interests include studies of vaccine-induced malaria immunity as well as the development and optimisation of subunit vaccines against the blood-stage of malaria infection.
At St Peter’s, I help our students to consolidate from basic to specialized concepts in biophysics and protein structure. Primarily, I teach biophysical and biological chemistry in the first year and structure and function of macromolecules in years 2 and 3 of the biochemistry course.
Plasmodium falciparum causes the severe form of malaria, responsible for over 400,000 deaths annually. Multiple lifecycle stages of the P. falciparum human malaria parasite are susceptible to antibody responses. Symptomatic malaria arises during the blood-stage, where merozoites of P. falciparum invade RBCs in a complex multistep process, which involves multiple interactions of parasite surface proteins and host receptors. A significant challenge for vaccine immunologists is the identification of effective formulations of an antigen that can induce the high levels of antibody required to protect against complex parasites.
My work is focused in the identification of improved antigen targets within the blood-stage merozoite malaria parasite; and the development, production and translation of structure-guided protein based vaccines according to good manufacturing practice (GMP) standards into the clinic.
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